TABLE 2.
Species | Voriconazole MIC (mg/liter) for indicated fluconazole susceptibility categoryb |
||||||||
---|---|---|---|---|---|---|---|---|---|
S (n = 3,247) |
I (n = 261) |
R (n = 718) |
|||||||
MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | |
Candida albicans | 0.015 | 0.015 | 0.015-1.0 | 0.03 | 1.0 | 0.015-1.0 | 0.25 | >8.0 | 0.015->8.0 |
Candida parapsilosis | 0.015 | 0.03 | 0.015-0.12 | 0.12 | 0.25 | 0.015-0.25 | 0.25 | 2.0 | 0.03->8.0 |
Candida tropicalis | 0.015 | 0.06 | 0.015-0.50 | 0.25 | 2.0 | 0.015-2.0 | 2.0 | >8.0 | 0.015->8.0 |
Candida glabrata | 0.06 | 0.25 | 0.015-0.50 | 0.12 | 0.25 | 0.03-0.50 | 0.25 | 4.0 | 0.015->8.0 |
Candida kruseic | 0.25 | 1.0 | 0.015-4.0 | ||||||
Total | 0.015 | 0.03 | 0.015-0.50 | 0.12 | 0.25 | 0.015-2.0 | 0.50 | 4.0 | 0.015->8.0 |
See reference 17.
S, fluconazole-susceptible strains (MIC ≤ 2); I, fluconazole-intermediate strains (MIC = 4); R, fluconazole-resistant strains (MIC > 8); MIC50, concentration causing inhibition of 50% of isolates; MIC90, concentration causing inhibition of 90% of isolates.
C. krusei is intrinsically resistant to fluconazole.