TABLE 1.

The origins and characteristics of 32 qnrS1-bearing plasmids

Strain or plasmid identification no.	Plasmid name	Sourcea	Bacterial speciesb	Incompatibility group(s)c	Size (kbp)	Presence of ESBL	MIC (μg/ml)		Resistance patternd
							NAL	CIP
Strain
Top10			E. coli			−	1.5	0.006
Plasmids
LTMV1	pEW62RMAN	Community	K. pneumoniae	A/C	9	−	6	0.38	CIPL
LTMV2	p033CA22	Community	E. coli	FIA; A/C	101	−	4	0.25	CHL, TET, SXT, CIPL
LTMV3	p036CN2	Community	E. coli	repF; HI1; FIA; A/C	80	−	12	0.38	CHL, GEN, CIPL
LTMV4	pA003IaI	Community	K. pneumoniae	FIA; A/C; R	132	−	4	0.25	CHL, GEN, TET, SXT, CIPL
LTMV5	pK261An	Hospital	K. pneumoniae	R	70	−	4	0.25	AMP, CHL, GEN, TET, SXT, CIPL
LTMV6	p023CN2	Community	E. coli	repF; FIB	140	−	4	0.25	AMP, CHL, CIPL
LTMV7	p038CN2	Community	K. pneumoniae	R	64	−	4	0.25	AMP, CHL, GEN, TET, SXT, CIPL
LTMV8	p008CN1	Community	E. coli	repF; FIB	140	−	8	0.38	CHL, GEN, CIPL
LTMV9	p001CN2	Community	E. coli	Unknown	96	−	4	0.38	AMP, CHL, GEN, TET, CIPL
LTMV11	p024CAZZ	Community	E. coli	FIA	44	−	6	0.38	AMP, TET, SXT, CIPL
LTMV12	p0022IbI	Community	K. pneumoniae	Unknown	98	−	4	0.25	AMP, TET, SXT, CIPL
LTMV13	p045CN2	Community	E. coli	repF	107	−	6	0.25	AMP, CHL, CIPL
LTMV14	pK233Ca	Hospital	K. pneumoniae	Unknown	51	+	4	0.12	AMP, GEN, CRO, CIPL
LTMV15	p025CN1	Community	E. coli	Unknown	135	−	6	0.38	AMP, CHL, TET, SXT, CIPL
LTMV16	p065CN2	Community	K. pneumoniae	Unknown	71	−	4	0.25	AMP, CHL, GEN, TET, CIPL
LTMV17	p048CN2	Community	E. coli	R	26	−	6	0.38	CHL, CIPL
LTMV18	pE18An	Hospital	E. coli	Unknown	58	−	4	0.25	AMP, CIPL
LTMV19	pD025IaI	Community	E. coli	Unknown	130	−	6	0.38	AMP, CHL, GEN, TET, SXT, CIPL
LTMV20	p051CN	Community	E. coli	R; ColE	108	−	4	0.25	AMP, CHL, GEN, TET, SXT, KAN, CIPL
LTMV21	pK300N	Hospital	K. pneumoniae	R	57	+	6	0.25	AMP, FEP, GEN, TIC, CRO, CIPL
LTMV23	p039CN2	Community	E. coli	Unknown	109	−	4	0.25	AMP, CHL, GEN, TET, TIC, SXT, KAN, CIPL
LTMV24	p008Na2	Community	E. coli	Unknown	43	−	6	0.12	AMP, CIPL
LTMV25	pA0001IaI	Community	E. coli	Unknown	118	−	3	0.25	AMP, CHL, GEN, SXT, CIPL
LTMV26	pB011IaI	Community	E. coli	Y	103	−	3	0.25	AMP, CHL, GEN, CIPL
LTMV27	pEW20NMAG	Community	K. pneumoniae	Unknown	132	−	4	0.25	AMP, GEN, TET, SXT, KAN, CIPL
LTMV28	pK18An	Hospital	K. pneumoniae	N	58	−	4	0.25	GEN, CIPL
LTMV29	pE66An	Hospital	E. coli	N	87	+	4	0.25	AMP, FEP, GEN, TET, SXT, CRO, CIPL
LTMV30	pK218Ca	Hospital	K. pneumoniae	A/C	48	−	4	0.12	GEN, CIPL
LTMV31	pK218Ca	Hospital	K. pneumoniae	N	60	+	6	0.38	AMP, FEP, GEN, CRO, CIPL
LTMV32	pK79N	Hospital	K. pneumoniae	N	74	+	6	0.38	AMP, FEP, GEN, TET, SXT, CRO, CIPL
LTMV33	pK263Ax	Hospital	K. pneumoniae	Unknown	49	−	6	0.19	GEN, CIPL
LTMV34	pK279N	Hospital	K. pneumoniae	Unknown	105	+	4	0.25	AMP, FEP, GEN, CRO, CIPL

^aLocation of isolation of the original bacterial isolate containing qnrS1-carrying plasmid (12).

^bOriginal bacterial species from which the qnrS1-carrying plasmid was isolated.

^cIncompatibility group determined by PCR (4).

^dNAL, nalidixic acid; CIP_L, reduced susceptibility to ciprofloxacin; CHL, chloramphenicol; TET, tetracycline; SXT, trimethoprim-sulfamethoxazole; GEN, gentamicin; AMP, ampicillin; CRO, ceftriaxone; KAN, kanamycin; FEP, cefepime; TIC, ticarcillin.