TABLE 2.

Efficacies of NAI-107 and comparator agents in murine lethal infection models induced by Gram-positive pathogens in immunocompetent or neutropenic animals

Strain	Compound	Route	ED50 (mg/kg) (95% confidence limits)
S. aureus GISA 4061b	NAI-107	i.v.	14.2 (11.9-16.9)
		s.c.	25.1 (21.6-29.6)
	Linezolid	p.o.c	17.8 (15.3-20.8)
	Vancomycin	s.c.	22.4 (18.0-27.9)
E. faecium VanA 569	NAI-107	i.v.	2.3 (1.7-3.0)
		s.c.	4.5 (3.5-5.6)
	Linezolid	p.o.	5.1a
E. faecalis VanA A533	NAI-107	i.v.	2.8 (2.4-3.3)
		s.c.	8.0 (6.1-10.5)
	Linezolid	p.o.	22.4 (18.6-27.0)
S. pneumoniae 2868	NAI-107	i.v.	0.51 (0.42-0.62)
		s.c.	1.1 (1.0-1.4)
	Linezolid	p.o.	15.9 (12.2-20.7)
	Penicillin G	s.c.	31.6 (27.2-36.7)

^aThe confidence limits could not be calculated because survival in all treated groups was either 0 or 100%.

^bInfection was performed in neutropenic mice.

^cp.o., per os.