FIG. 2.

S. aureus peptidoglycan synthesis and targets of cell wall-active antibiotics. The inhibition of enzymatic reactions is indicated by blocked arrows; the inhibition of cell wall synthesis by the binding of antibiotics to peptidoglycan precursors is indicated by half-moon symbols; pentaglycine bridge cleavage by lysostaphin and membrane disruption/depolarization by daptomycin are indicated by arrows. (Adapted from reference 31 with the permission of the publisher.)