TABLE 2.

Characteristics of CF patients with S. aureus respiratory infection who were treated with LZD from 2000 to 2006

Characteristic	All patients (n = 77)	Patients with LRSA infection (n = 8)	Patients with LSSA infection (n = 69)	P valuea
No. (%) patients of female gender	41 (53.3)	4 (50.0)	37 (53.6)	1.0
Mean ± SD age (yr)b	14.6 ± 9.6	13.6 ± 9.0	14.8 ± 9.8	0.62
No. (%) of patients with delta F508c	45 (58.4)	4 (50.0)	41 (59.4)	0.71
No. (%) of Caucasian patients	74 (96.0)	8 (100)	66 (95.7)	1.0
LZD courses in 7 yr
Mean ± SD	7.2 ± 8.2	18.8 ± 14.1	5.9 ± 6.1	0.001
Median (interquartile range)	4 (1-11)	15.5 (8-27)	4 (1-8)
LZD exposure over 7 yr (days)d
Mean ± SD	245.9 ± 331.3	546.5 ± 240.2	211.0 ± 323.8	<0.001
Median (interquartile range)	98 (35-336)	467 (371-691)	74 (28-205)
LZD exposure/yr in pre-LRSA period (days)d
Mean ± SD	35.6 ± 49.1	83.1 ± 50.0	30.1 ± 46.3	<0.001
Median (interquartile range)	14 (5-45)	75 (44-116)	11 (4-29)
Additional no. of antibiotics over 7 yr
Mean ± SD	6.0 ± 9.6	13 ± 20.0	5.2 ± 7.4	0.07
Median (interquartile range)	3 (1-8)	8 (4-9)	2 (1-7)
Additional no. of antibiotics/yr in pre-LRSA period
Mean ± SD	0.9 ± 1.7	2.3 ± 4.3	0.7 ± 1.0	0.11
Median (interquartile range)	0.4 (0.1-1.0)	0.8 (0.5-1.7)	0.3 (0.1 ± 1.0)
No. of hospitalizations in 7 yr
Mean ± SD	6.4 ± 9.1	12.8 ± 19.6	5.7 ± 6.9	0.18
Median (interquartile range)	3 (1-10)	6 (2.5-12)	3 (1-10)
No. of hospitalizations/yr in pre-LRSA period
Mean ± SD	0.9 ± 1.5	2.0 ± 3.7	0.8 ± 1.0	0.38
Median (interquartile range)	0.4 (0.1 ± 1.4)	0.7 (0.2 ± 1.8)	0.4 (0.1 ± 1.4)
No. (%) of patient deaths	5 (6.5)	1 (12.5)	4 (5.8)
No. (%) of patient lung transplants	8 (10.4)	2 (25.0)	6 (8.7)

^aComparison of LRSA and LSSA groups using Wilcoxon rank-sum or Fisher's exact test.

^bAge at the midpoint of the year 2000.

^cHomozygous.

^dCumulative.