FIG. 6.

Replication kinetics of GRL-1398-resistant HIV-1 variants and HIV-1_NL4-3. MT-4 cells were exposed to HIV-1_{GRL1398-1μM^Exp.I} (left panel, closed symbols), HIV-1_{GRL1398-1μM^Exp.II} (right panel, closed symbols), or wild-type HIV-1_NL4-3 (WT, ○) for 3 h, and each MT-4 cell population was cultured in the presence of 0.1 μM (▪) or 1 μM (▴) of GRL-1398 or without the agent (•). The amounts of p24 were measured every 2 days for up to 8 or 10 days. Note that HIV-1_NL4-3 failed to replicate in the presence of 0.1 and 1 μM GRL-1398 (□ and ▵, respectively), both HIV-1_{GRL1398-1μM^Exp.I} and HIV-1_{GRL1398-1μM^Exp.II} replicated in the presence of GRL-1398.