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Structural analysis of GRL-1388 and -1398 modeled into the active-site cavity of wild-type HIV-1 protease. GRL-1388 (a) and GRL-1398 (b) are shown as stick models (white color). Protease residues involved in either hydrogen bonding or hydrophobic interactions are highlighted in green. The distances for selected hydrogen bonds are shown. The novel Tp-THF functional group in both the compounds shows strong hydrogen bonding interactions with the backbone of residues Asp29 and Asp30.
