TABLE 1.
Antiviral activities of GRL-1388 and -1398 against HIV-1LAI and their cytotoxicities in vitroa
| Drug | Mean ± SD |
Selectivity indexb | |
|---|---|---|---|
| EC50 (nM) | CC50 (μM) | ||
| SQV | 6.2 ± 1.9 | 19.7 ± 6.1 | 3,200 |
| APV | 19.6 ± 3.9 | >100 | >5,100 |
| ATV | 5.0 ± 1.9 | 27.6 ± 0.7 | 5,500 |
| DRV | 3.3 ± 0.9 | >100 | >30,300 |
| GRL-1388 | 3.6 ± 1.8 | >100 | >27,800 |
| GRL-1398 | 0.2 ± 0.2 | 37.7 ± 2.7 | 188,500 |
a
All assays were conducted in duplicate, and the data shown represent mean values (±1 standard deviation) derived from the results of three independent experiments.
b
Each selectivity index denotes a ratio of CC50 to EC50 against HIV-1LAI.