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. 2011 Jan 24;55(4):1747–1753. doi: 10.1128/AAC.01629-10

FIG. 2.

FIG. 2.

Individual-fitted viral loads for zanamivir against oseltamivir-resistant H1N1 influenza virus in the hollow-fiber infection model. (A and B) Graphs based on the dose fractionation study described in Materials and Methods. A 1,200-mg/day dose of zanamivir was fractionated at Q24h, Q12h, and Q8h dosing intervals with a simulated 2.5-h (A) or 8-h (B) half-life for zanamivir. (C and D) Graphs based on the dose range study described in the companion paper (5). In this study, a total daily dose of 300 mg, 600 mg, or 1,200 mg of zanamivir was administered Q24h (C) or Q12h (D). A half-life of 2.5 h was simulated for zanamivir in this study.