TABLE 2.
Population pharmacokinetic parameters for intubated patients with hospital-acquired pneumoniaa
| Parameter (n = 39) | Vc (liters) | CL (liters/h) | K12 (h−1) | K21 (h−1 h−1) | K13 (h−1) | K31 (liters) | VELF (liters) |
|---|---|---|---|---|---|---|---|
| Mean | 12.6 | 15.2 | 8.3 | 14.1 | 10.1 | 14.2 | 30.4 |
| Median | 6.7 | 13.5 | 3.2 | 11.2 | 8.0 | 15.4 | 24.2 |
| SD | 13.3 | 9.7 | 9.8 | 11.7 | 8.6 | 11.4 | 25.2 |
a
Vc, volume of distribution in the central compartment; CL, meropenem clearance from plasma; K12, K21, K13, and K31, first-order intercompartmental transfer rate constants; VELF, volume of distribution in the ELF compartment.