TABLE 3.
Estimation of penetration of meropenem into ELF using a Monte Carlo simulationa
| Parameter | AUCplasma (mg·h/liter) | AUCELF (m·h/liter) | Penetration ratio (%) |
|---|---|---|---|
| Mean | 150.8 | 82.30 | 81.6 |
| Median | 130.9 | 35.00 | 25.42 |
| SD | 87.40 | 140.1 | 223.0 |
| 95% CI of the mean | 149.1-152.5 | 79.55-85.04 | 77.28-86.02 |
| Percentile | |||
| 10th | 63.90 | 4.76 | 3.67 |
| 25th | 90.14 | 12.52 | 9.00 |
| 50th | 130.90 | 35.00 | 25.42 |
| 75th | 189.30 | 92.10 | 70.14 |
| 90th | 262.10 | 204.70 | 177.90 |
a
AUC, area under the concentration-time curve; Penetration ratio, AUCELF/AUCplasma; CI, confidence interval.