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Efficacy of antibiotic-mediated cure of septic guinea pigs. Animals were intranasally infected with Vollum spores, and following the development of septicemia, the animals were treated for 21 days with doxycycline (A and D), ciprofloxacin (B and E), or ciprofloxacin and anti-PA antibodies (C and F). The results are expressed as individual bacteremia levels (A to C) and serum PA levels (D to F) of each animal prior to initiation of treatment. GPαPA, guinea pig anti-PA.
