Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Probabilities of Cmin,48 and Cmin,72 values exceeding 24.3 mg/liter
| Regimen and parametera |
P value |
|
|---|---|---|
| 4 mg/kg | 6 mg/kg | |
| Pre-HD | ||
| Cmin,48 | 0.0000 | 0.0011 |
| Cmin,72 | 0.0000 | 0.0000 |
| Intra-HD | ||
| Cmin,48 | 0.0004 | 0.0098 |
| Cmin,72 | 0.0000 | 0.0002 |
| Post-HD | ||
| Cmin,48 | 0.0006 | 0.0230 |
| Cmin,72 | 0.0000 | 0.0007 |
| SAB-IE (non-HD) | ||
| Cmin,48 | 0.0039 | 0.0293 |
| Cmin,72 | 0.0089 | 0.0516 |
Simulations for HD candidate regimens were based on one dose. Simulations for non-HD regimens were based on intravenous dosing q24h for 3 days.
