TABLE 1.

In vitro activities of components of BAL30376

Strain	Enzyme(s) present	MIC of BAL19764 (μg/ml) in combination with:
		Alone	BAL29880 at 4 μg/ml	Clavulanate at 2 μg/ml	BAL29880 at 4 μg/ml + clavulanate at 2 μg/ml	BAL29880 + clavulanate
						1:1:1 (wt/wt/wt)	5:4:1 (wt/wt/wt)	5:3:1 (wt/wt/wt)	5:2:1 (wt/wt/wt)	10:10:3 (wt/wt/wt)	10:10:2 (wt/wt/wt)	10:10:1 (wt/wt/wt)
Acinetobacter baumannii J2	ADC	32	4	32	4	8	4	8	16	NTa	NT	NT
Acinetobacter junii 15218	None	0.5	0.5	0.5	NT	NT	NT	0.5	NT	NT	NT	NT
Citrobacter freundii GN7391	AmpC	>32	4	>32	4	16	8	16	32	NT	NT	NT
Enterobacter aerogenes B1	AmpC	>32	2	>32	2	2	4	4	8	NT	NT	NT
Enterobacter cloacae P99	AmpC	32	2	32	2	4	4	4	8	NT	NT	NT
E. cloacae 908R	AmpC	>32	1	32	1	2	1	1	4	NT	NT	NT
E. cloacae R947	TEM-1, IMP-8, AmpC	>32	32	2	2	2	2	4	8	2	4	8
E. cloacae S9615	AmpC	32	2	>32	NT	NT	NT	2	NT	NT	NT	NT
E. cloacae S4741B	AmpC	8	1	8	NT	1	1	0.5	NT	NT	NT	NT
E. cloacae S9639	AmpC	32	2	>32	NT	NT	NT	2	NT	NT	NT	NT
Escherichia coli HB101(pAT268)	TEM-5	>32	>32	1	1	1	4	4	4	2	4	4
Klebsiella oxytoca 1082E	K1	>32	>32	0.5	1	1	8	8	8	4	8	16
Klebsiella pneumoniae CF104	TEM-3	>32	>32	2	NT	NT	NT	2	NT	NT	NT	NT
K. pneumoniae CF504	A	>32	>32	0.5	1	1	2	2	2	2	2	4
K. pneumoniae 55	SHV-1, VIM-1	>32	>32	8	NT	NT	NT	4	NT	NT	NT	NT
K. pneumoniae 848	SHV-1, VIM-1	>32	>32	4	4	4	4	8	16	8	8	16
Pseudomonas aeruginosa BA	AmpCb	2	1	2	1	2	2	1	1	NT	NT	NT
P. aeruginosa 18 S/H	AmpC	16	2	>32	2	4	4	8	8	NT	NT	NT
P. aeruginosa 527	IMP-1, PSE-1, AmpCb	2	2	4	NT	4	NT	2	NT	NT	NT	NT
P. aeruginosa 860	AmpC	8	1	8	2	2	4	4	4	NT	NT	NT
P. aeruginosa 1973E (PSE1)	PSE1, AmpC	8	8	8	4	NT	NT	8	NT	NT	NT	NT
P. aeruginosa 1937E (PSE2)	PSE2, AmpC	8	8	4	4	NT	NT	2	NT	NT	NT	NT
P. aeruginosa 6067	AmpC	8	4	8	NT	4	NT	4	NT	NT	NT	NT
P. aeruginosa 143724R	AmpC, porin alteration	32	NT	NT	NT	8	NT	8	NT	NT	NT	NT
P. aeruginosa 143811R	AmpC	>32	2	>32	2	4	4	4	8	NT	NT	NT
P. aeruginosa (560546)9 M.P.	AmpC	16	2	16	NT	2	2	2	NT	NT	NT	NT
Stenotrophomonas maltophilia 1AC736	L1, L2	2	2	0.125	NT	NT	NT	0.125	NT	NT	NT	NT

^aNT, not tested.

^bLow-level expression.