TABLE 2.
Activity of BAL30376 against strains with β-lactam-resistant phenotypes
| Organism (no. of isolates) and compound | MICa (μg/ml) |
||
|---|---|---|---|
| 50% | 90% | Range | |
| Citrobacter freundii (21) | |||
| BAL30376 | 2 | 8 | ≤0.06-16 |
| Imipenem | 1 | 2 | 0.5-4 |
| Meropenem | ≤0.06 | 0.25 | ≤0.06-4 |
| Cefepime | 1 | 4 | ≤0.06-8 |
| Ceftazidime | >32 | >32 | >32 |
| Piperacillin-tazobactam (8:1) | >32 | >32 | >32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | >32 |
| Ticarcillin-clavulanic acid (15:1) | >32 | >32 | >32 |
| Enterobacter aerogenes (15) | |||
| BAL30376 | 0.5 | 2 | ≤0.06-8 |
| Imipenem | 2 | 16 | 0.5-32 |
| Meropenem | 0.25 | 4 | ≤0.06-16 |
| Cefepime | 0.25 | 16 | ≤0.06-16 |
| Ceftazidime | >32 | >32 | 0.125->32 |
| Piperacillin-tazobactam (8:1) | 32 | >32 | 4->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | >32 |
| Ticarcillin-clavulanic acid (15:1) | >32 | >32 | >32 |
| Enterobacter cloacae (25) | |||
| BAL30376 | 1 | 4 | ≤0.06-16 |
| Imipenem | 2 | 4 | 0.25-16 |
| Meropenem | ≤0.06 | 0.25 | ≤0.06-16 |
| Cefepime | 0.25 | 4 | ≤0.06->32 |
| Ceftazidime | 16 | >32 | 0.125->32 |
| Piperacillin-tazobactam (8:1) | 16 | >32 | 4->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | >32 |
| Ticarcillin-clavulanic acid (15:1) | >32 | >32 | >32 |
| Escherichia coli (18) | |||
| BAL30376 | 1 | 4 | ≤0.06->32 |
| Imipenem | 0.25 | 0.5 | ≤0.06->32 |
| Meropenem | ≤0.06 | 0.5 | ≤0.06->32 |
| Cefepime | 8 | >32 | ≤0.06->32 |
| Ceftazidime | 32 | >32 | 1->32 |
| Piperacillin-tazobactam (8:1) | 32 | >32 | 4->32 |
| Amoxicillin-clavulanic acid (2:1) | 32 | >32 | 16->32 |
| Ticarcillin-clavulanic acid (15:1) | 32 | >32 | 32->32 |
| Klebsiella oxytoca (10) | |||
| BAL30376 | 0.5 | 4 | ≤0.06->32 |
| Imipenem | 0.5 | 1 | 0.5->32 |
| Meropenem | 0.25 | 8 | ≤0.06->32 |
| Cefepime | 2 | 8 | ≤0.06->32 |
| Ceftazidime | 1 | 8 | ≤0.06->32 |
| Piperacillin-tazobactam (8:1) | 4 | >32 | 2->32 |
| Amoxicillin-clavulanic acid (2:1) | 8 | >32 | 4->32 |
| Ticarcillin-clavulanic acid (15:1) | 8 | >32 | 4->32 |
| Klebsiella pneumoniae (39) | |||
| BAL30376 | 0.5 | 4 | ≤0.06->32 |
| Imipenem | 1 | 16 | 0.5->32 |
| Meropenem | ≤0.06 | 16 | ≤0.06->32 |
| Cefepime | 4 | >32 | ≤0.06->32 |
| Ceftazidime | >32 | >32 | 0.125->32 |
| Piperacillin-tazobactam (8:1) | 32 | >32 | 1->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | 8->32 |
| Ticarcillin-clavulanic acid (15:1) | >32 | >32 | 8->32 |
| Proteus spp. (21)b | |||
| BAL30376 | 0.125 | 1 | ≤0.06-2 |
| Imipenem | 4 | 8 | 0.5-8 |
| Meropenem | 0.125 | 0.5 | ≤0.06-0.5 |
| Cefepime | 0.125 | 1 | ≤0.06-32 |
| Ceftazidime | ≤0.06 | 0.25 | ≤0.06-8 |
| Piperacillin-tazobactam (8:1) | 1 | 4 | ≤0.06-32 |
| Amoxicillin-clavulanic acid (2:1) | 32 | >32 | 8->32 |
| Ticarcillin-clavulanic acid (15:1) | 8 | >32 | 1->32 |
| Providencia spp. (20)c | |||
| BAL30376 | ≤0.06 | 0.5 | ≤0.06-4 |
| Imipenem | 4 | 16 | 1->32 |
| Meropenem | 0.25 | >32 | ≤0.06->32 |
| Cefepime | ≤0.06 | >32 | ≤0.06->32 |
| Ceftazidime | 1 | >32 | ≤0.06->32 |
| Piperacillin-tazobactam (8:1) | 4 | 32 | 0.5->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | >32 |
| Ticarcillin-clavulanic acid (15:1) | 16 | >32 | 0.5->32 |
| Serratia marcescens (12) | |||
| BAL30376 | 1 | 2 | 0.5-4 |
| Imipenem | 2 | 8 | 0.5->32 |
| Meropenem | 0.125 | 4 | ≤0.06->32 |
| Cefepime | 1 | 2 | 0.125-16 |
| Ceftazidime | 1 | 2 | 0.125->32 |
| Piperacillin-tazobactam (8:1) | >32 | >32 | 4->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | >32 |
| Ticarcillin-clavulanic acid (15:1) | >32 | >32 | 8->32 |
| Acinetobacter spp. (68) | |||
| BAL30376 | 4 | 16 | ≤0.06->32 |
| Imipenem | 0.25 | 32 | ≤0.06->32 |
| Meropenem | 1 | 16 | ≤0.06->32 |
| Cefepime | 16 | >32 | ≤0.06->32 |
| Ceftazidime | 16 | >32 | ≤0.06->32 |
| Piperacillin-tazobactam (8:1) | >32 | >32 | 8->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | 8->32 |
| Ampicillin/sulbactam (2:1) | 16 | >32 | 2->32 |
| Polymyxin B | 4 | 32 | ≤0.06->32 |
| Burkholderia spp. (20) | |||
| BAL30376 | 0.5 | 16 | 0.25->32 |
| Imipenem | 32 | >32 | 16->32 |
| Meropenem | 2 | 4 | 0.25-8 |
| Cefepime | 8 | 16 | 4-32 |
| Ceftazidime | 2 | 8 | 0.25-8 |
| Piperacillin-tazobactam (8:1) | 8 | 32 | 2->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | >32 |
| Ticarcillin-clavulanic acid (15:1) | >32 | >32 | >32 |
| Pseudomonas aeruginosa (158) | |||
| BAL30376 | 2 | 8 | ≤0.06->32 |
| Imipenem | 4 | 16 | 0.5->32 |
| Meropenem | 1 | 8 | ≤0.06->32 |
| Cefepime | 8 | 32 | 0.5->32 |
| Ceftazidime | 4 | >32 | 0.25->32 |
| Piperacillin-tazobactam (8:1) | 16 | >32 | 0.5->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | >32 |
| Ticarcillin-clavulanic acid (15:1 | >32 | >32 | >32 |
| Polymyxin B | 4 | 4 | 1->32 |
| Stenotrophomonas maltophilia (105) | |||
| BAL30376 | 0.25 | 2 | ≤0.06-16 |
| Imipenem | >32 | >32 | 32->32 |
| Meropenem | 8 | >32 | 0.25->32 |
| Cefepime | 16 | >32 | 2->32 |
| Ceftazidime | 2 | 16 | 0.5->32 |
| Piperacillin-tazobactam (8:1) | 32 | >32 | 4->32 |
| Amoxicillin-clavulanic acid (2:1) | >32 | >32 | >32 |
| Ticarcillin-clavulanic acid (15:1) | 2 | 16 | 0.25->32 |