TABLE 3.

Activity of BAL30376 against strains with identified β-lactamases as the sole determinant of β-lactam resistance

Organism	Enzyme(s) present	MICa (μg/ml)
		BAL30376	MEM	IMP
E. coli HB101(pAT268)	TEM-5	2	≤0.06	0.25
E. coli HB101(pAT266)	TEM-4	8	≤0.06	0.5
E. coli K802N(pAT251)	TEM-3	0.5	≤0.06	0.25
E. coli AC133	CTX-M-15	1	≤0.06	1
K. pneumoniae 1357E	TEM-10	0.25	≤0.06	0.5
K. pneumoniae HPA721	TEM-29, SHV-14	0.125	≤0.06	1
K. pneumoniae 26768WU	SHV-5	4	≤0.06	1
K. oxytoca 1028E	K1	4	0.125	0.5
P. aeruginosa 1973E	PSE-1, AmpC	8	4	2
P. aeruginosa 1559E	PSE-4, AmpC	2	1	2
S. marcescens S6	SME-1, AmpC	0.25	32	>32
E. coli NMCA	NMCA	2	>32	>32
K. pneumoniae YC	KPC-2, SHV-2, TEM-1	>32	>32	>32
A. baumannii HPA74510	IMP-4	0.5	32	16
E. cloacae R947	IMP-8, TEM-1, AmpC	2	1	8
P. aeruginosa HPA101-1477	IMP-1, AmpC	1	>32	>32
P. aeruginosa HPA10586	VIM-1, AmpC	2	>32	>32
P. aeruginosa HPA996	VIM-2, AmpC	0.5	32	>32
K. pneumoniae 848	VIM-1, SHV-1	2	32	>32
P. rettgeri J96	IMP-1	1	>32	>32
S. maltophilia B715	L1, L2	0.25	>32	>32
E. cloacae 908R	AmpC	1	0.125	1
E. cloacae ATCC 13047	AmpC	1	1	1
E. cloacae ATCC 13047/CRO-R	AmpC, porin-	16	2	8
E. coli Libyien	CMY-2	1	0.125	1
P. aeruginosa 143811R	AmpC	2	0.125	0.5
P. aeruginosa 18S/H	AmpC	2	2	4
P. aeruginosa 143724R	AmpC	8	4	8
S. marcescens 1T9	AmpC	1	0.125	1
P. aeruginosa 1937E	PSE-2, AmpC	2	4	4
A. baumannii HPA327009	OXA-25	32	>32	>32
A. baumannii HPA4737	OXA-26	>32	>32	>32
A. baumannii HPAI-16	OXA-27	2	>32	>32
A. baumannii MAD (PN)	OXA-58	1	8	>32

^aExpressed as the concentration of BAL19764 for BAL30376. MEM, meropenem; IMP, imipenem.