TABLE 6.
Resistance development in serial passage
| Organism |
BAL30376a |
Meropenem selection |
Cefepime selection |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selection |
Reversion |
|||||||||||
| MIC (μg/ml) |
No. of passages | MIC (μg/ml) |
No. of passages | MIC (μg/ml) |
No. of passages | MIC (μg/ml) |
No. of passages | |||||
| Initial | Final | Initial | Final | Initial | Final | Initial | Final | |||||
| A. baumannii HPA74510 | 0.5 | 64 | 20 | Not tested | Not tested | Not tested | ||||||
| 64 | 9 | 4 | 0.5 | 3 | ||||||||
| A. junii 15218 | 0.5 | 2 | 20 | Not tested | 0.125 | 0.5 | 20 | 0.5 | 8 | 20 | ||
| E. cloacae R947 | 2 | 8 | 20 | Not tested | 0.5 | 64 | 4 | Not tested | ||||
| 64 | 4 | 8 | 8 | 5 | 64 | 5 | ||||||
| E. cloacae S4741B | 1 | 8 | 20 | Not tested | 0.03 | 8 | 20 | 0.03 | 256 | 9 | ||
| 64 | 16 | |||||||||||
| E. cloacae S9639 | 2 | 8 | 20 | Not tested | 0.03 | 16 | 20 | 0.03 | 8 | 20 | ||
| K. pneumoniae 55 | 1 | 2 | 20 | Not tested | Not tested | Not tested | ||||||
| 64 | 7 | 16 | 4 | 5 | ||||||||
| K. pneumoniae CF104 | 4 | 8 | 20 | Not tested | 0.015 | 1 | 20 | Not tested | ||||
| P. aeruginosa 527 | 4 | 128 | 6 | 32 | 32 | 5 | 2 | 128 | 2 | 4 | 64 | 2 |
| 64 | 7 | 32 | 32 | 5 | ||||||||
| P. aeruginosa | 2 | 64 | 4 | 2 | 2 | 64 | 3 | Not tested | ||||
| (560546)9 M.P. | 2 | 16 | 10 | 16 | 16 | 16 | ||||||
| S. maltophilia 1AC736 | 0.125 | 16 | 20 | Not tested | 1 | 256 | 4 | |||||
| 64 | 7 | 8 | 8 | 5 | ||||||||
a
MIC expressed as the concentration of BAL19764.