TABLE 8.
Activities of BAL19764-BAL29880-clavulanic acid (1:1:1) and reference compounds against experimental septicemia in mice
| Strain (no. of CFU/mouse) and compound | MIC (μg/ml) | MBC (μg/ml) | Lowest dose affording protection (mg/kg t.i.d.a) |
|---|---|---|---|
| A. baumannii HPA74510 (4 × 105) | |||
| BAL19764-BAL29880-clavulanate | 0.5 | 2 | <3.1 |
| Meropenem | 32 | >32 | 3.1 |
| A. baumannii J2 (1 × 103) | |||
| BAL19764-BAL29880-clavulanate | 8 | 32 | 3.1 |
| Meropenem | 1 | 16 | <1.6 |
| Aztreonam | >32 | >32 | >3.1 |
| E. cloacae R947 (1 × 103) | |||
| BAL19764-BAL29880-clavulanate | 2 | 8 | <0.8 |
| Meropenem | 0.5 | 8 | <0.4 |
| Aztreonam | >32 | >32 | >0.4 |
| E. cloacae S9615 (1 × 107), BAL19764-BAL29880-clavulanate | 1 | 4 | 0.8 |
| P. aeruginosa 527 (1 × 107), BAL19764-BAL29880-clavulanate | 4 | 4 | 1.6 |
| P. aeruginosa HPA101-1477 (1 × 107) | |||
| BAL19764-BAL29880-clavulanate | 1 | >32 | 6.25 |
| Meropenem | >32 | >32 | >12.5 |
| Imipenem | >32 | >32 | >12.5 |
a
t.i.d., three times a day.