TABLE 6.
Post hoc Bayesian predicted PK parameters for SDX and NSX in PNG infants given conventional and double dosing of SDX/PYR
| Parameter | Result [median (IQR)] for study group |
P valuea | |
|---|---|---|---|
| Conventional dosing (n = 35) | Double dosing (n = 35) | ||
| CLT,SDX/F (liters/h) | 0.0068 (0.0057-0.0087) | 0.0072 (0.0068-0.0105) | 0.032 |
| VSDX/F (liters) | 2.20 (1.95-2.53) | 2.23 (1.97-2.64) | NS |
| t1/2 SDX (h) | 232 (203-252) | 207 (179-232) | 0.006 |
| AUC0-∞ SDX (mg/day/liters) | 1,460 (1,167-1,707) | 2,434 (1,881-2,987) | <0.001 |
| CLNSX/F (liters/h) | 0.081 (0.060-0.094) | 0.101 (0.081-0.116) | 0.012 |
| VNSX/F (liters) | 1.14 (1.00-1.28) | 1.17 (0.959-1.30) | NS |
| t1/2 NSX (h) | 10.3 (7.86-12.2) | 8.69 (6.84-10.6) | 0.027 |
| AUC0-∞ NSX (mg/day/liter) | 1,796 (1,397-2,154) | 2,890 (2,482-3,609) | <0.001 |
| AUC0-∞ NSX/AUC0-∞ SDX (%) | 5.0 (4.3-6.5) | 5.0 (4.3-6.0) | NS |
a
Mann-Whitney test. NS, nonsignificant (P > 0.05).