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. 2011 Jan 31;55(4):1494–1503. doi: 10.1128/AAC.01664-10

FIG. 7.

FIG. 7.

Clinically relevant doses of antibiotics affect eicosanoid metabolism. (A) Fecal levels of multiple eicosanoids were measured through ELISAs before and after high-dose streptomycin treatment. Dark gray bars, levels before treatment; light gray bars, levels after antibiotic treatment. Averages with standard errors of the means are shown. The numbers of mice used were as follows: CysLT before treatment, 11; CysLT after treatment, 6; PGE2 before and after treatment, 4 each; PGF2α before and after treatment, 6 each; LTB4 before and after treatment, 6 each. (B) Fecal levels of LTB4 were measured in groups of untreated mice and mice treated with clinically relevant doses of streptomycin (Strep), metronidazole (Met), vancomycin (Van), and tetracycline (Tet). Each dot represents one mouse, and bars indicate the averages of the results. **, P < 0.009; ***, P < 0.0001.