TABLE 2.
Effects of GS-8374 and marketed PIs on insulin-stimulated glucose uptake in mouse adipocytes in vitro
| Protease inhibitor | % inhibition of glucose uptake at 10 μMa |
|---|---|
| GS-8374 | −0.1 ± 0.1 |
| Darunavir | −0.7 ± 1.2 |
| Lopinavir | 44.0 ± 1.7 |
| Atazanavir | 0.3 ± 0.6 |
| Ritonavir | 60.7 ± 1.2 |
| Amprenavir | 8.1 ± 1.6 |
| Indinavir | 14.0 ± 12.5 |
| Nelfinavir | 28.4 ± 8.2 |
a
Data shown represent means ± standard deviations from three independent experiments. DMSO was used as a vehicle control; no effect on glucose uptake was observed in the presence of DMSO.