TABLE 3.
Comparison of glucose disposal in rats infused with GS-8374 or control PIs
| Treatment | Glucose concn in blooda (mg/dl) | Insulin concn (ng/ml) | Avg plasma exposurea (μM) | Glucose disposal rateb (mg/kg/min) | Glucose disposal rate (% of control) |
|---|---|---|---|---|---|
| Vehicle | 105.3 ± 7.4 | 4.62 ± 1.03 | NA | 47.1 ± 1.6 | 100 |
| GS-8374 | 105.6 ± 1.3 | 4.07 ± 2.19 | 7.7 ± 0.4 | 47.0 ± 0.2 | 99.7 |
| Atazanavir | 104.4 ± 3.3 | 5.21 ± 0.69 | 9.4 ± 1.5 | 46.6 ± 0.9 | 99.1 |
| Lopinavir | 103.3 ± 1.7 | 4.12 ± 2.40 | 10.9 ± 1.1 | 38.0 ± 0.6c | 80.8 |
| Ritonavir | 109.2 ± 1.6 | 3.65 ± 0.87 | 8.7 ± 0.4 | 22.3 ± 1.6c | 47.4 |
a
All values represent the means ± standard deviations from three and four different vehicle- and drug-treated animals, respectively. NA, not applicable.
b
Rate of glucose disposal (mg/kg/min) was averaged from measurements from the last 30 min of each experiment.
c
Statistically significant difference from vehicle-treated animals, as determined by ANOVA with the Bonferonni post hoc test (P < 0.01).