. 2011 Feb 7;55(4):1611–1621. doi: 10.1128/AAC.01022-10

TABLE 3.

Functional distribution of PFA-responding genes

GO category^a	PFA data set frequency (%)	Genome frequency (%)	P value	CaCl₂-, AMD-, and calcineurin/Crz1-associated genes
Upregulated genes
Response to stress	23.63	12.93	2.34 × 10⁻⁷	AGX1^b^,^cALD3^b^,^cARK1^c^,^dATG5^b^,^c^,^dBAG7^b^,^c^,^dDDR2^b^,^cDDR48^bDOT5^bECM4^bFMP45^b^,^cFMP46^bGRE1^bGRE2^b^,^cGTT1^bHBT1^bHOR2^b^,^dHSP12^b^,^cHSP26^b^,^dHSP31^b^,^cLAP4^bPBI2^bPRB1^b^,^c^,^dPRX1^bRSB1^cRTA1^b^,^c^,^dSCS3^dSDS24^b^,^cSNZ1^b^,^dSPI1^b^,^c^,^dTOS3^bUBC5^bUBI4^bUGA2^bXBP1^c^,^dYBR016W^dYBR056W^dYDL010W^dYER185W^b^,^c^,^dYET2^b^,^c^,^dYGP1^b^,^dYHR138C^b^,^c^,^dYJL068C^b^,^dYJL144W^b^,^c^,^dYJR096W^bYJR107W^dYMR090W^bYOR052C^b^,^c^,^dYOR338W^b^,^d
Transport	20.21	19.11	5.19 × 10⁻²	ADY2^cARK1^c^,^dATG5^b^,^c^,^dECM27^c^,^dENA5^c^,^dFLC1^dGIT1^dGSP2^bGYP7^b^,^c^,^dHES1^dHXT5^b^,^c^,^dIMP2^dJEN1^cKHA1^b^,^dMEP1^b^,^c^,^dMIG2^cODC1^bPBI2^bPDR10^c^,^dPEP12^b^,^c^,^dPMC1^b^,^dPRM8^b^,^c^,^dRCR1^b^,^c^,^dRSB1^cSDS24^b^,^cSGE1^b^,^dUBC5^bVPS36^c^,^dYBR287W^b^,^c^,^dYDL010W^dYER185W^b^,^c^,^dYET2^b^,^c^,^dYMR034C^cYOL162W^b^,^dYPT53^b^,^c^,^d
Carbohydrate metabolism	10.27	5.7	7.35 × 10⁻⁴	AMS1^b^,^c^,^dCAT8^c^,^dCHS1^b^,^c^,^dCRH1^dGND2^bGSC2^dHOR2^b^,^dMAL33^cMIG2^cMNT4^b^,^c^,^dNRG1^b^,^cOCH1^dSGA1^bSHC1^bTOS3^bYBR056W^b^,^dYGR043C^b^,^cYJR096W^bYMR085W^c^,^d
Transcription	8.56	11.67	1.87 × 10⁻²	CAT8^c^,^dCRZ1^dCSE2^b^,^dCSR2^c^,^dCUP2^b^,^c^,^dDOT5^bMAL33^cMIG1^cNRG1^b^,^cPCL5^b^,^dREG2^cVPS36^c^,^dXBP1^c^,^dYER184C^b^,^c^,^d
Protein modification	8.22	11.05	2.32 × 10⁻²	ARK1^c^,^dATG5^b^,^c^,^dCMK2^b^,^c^,^dHAL5^c^,^dMNT4^b^,^c^,^dOCH1^dSTB2^dTOS3^bUBC5^bUBI4^bUBP5^dVHS1^cYGR052W^b^,^cYMR291W^c
Organelle organization	7.53	18.09	1.26 × 10⁻⁷	ARK1^c^,^dBNA2^b^,^dCSE2^b^,^dGSP2^bPBI2^bPEP12^b^,^c^,^dSTB2^dTHI4^b^,^dYHR138C^b^,^c^,^d
Amino acid metabolism	6.85	4.2	1.07 × 10⁻²	AGX1^b^,^cALD3^b^,^cARO10^b^,^dARO9^bPUT1^b^,^c^,^dSNO1^dSPS100^b^,^c^,^dUGA2^bYGP1^b^,^dYHR033W^bYMR085W^c^,^dYMR090W^b
Membrane organization	5.82	4.01	3.31 × 10⁻²	ARK1^c^,^dATG5^b^,^c^,^dHES1^dPBI2^bPEP12^b^,^c^,^dRSB1^cSDS24^b^,^cUBC5^bYHR138C^b^,^c^,^dYPT53^b^,^c^,^d
Cell wall organization	5.48	3.27	1.55 × 10⁻²	CHS1^b^,^c^,^dCRH1^dCSR2^c^,^dECM27^c^,^dECM4^bFMP45^b^,^cGSC2^dOSW2^b^,^c^,^dRCR1^b^,^c^,^dSHC1^bSPS100^b^,^c^,^dYLR194C^b^,^c^,^dYPS3^b^,^c^,^d
Sporulation	5.14	2.63	6.29 × 10⁻³	FMP45^b^,^cGSC2^dOSW2^b^,^c^,^dPRB1^b^,^c^,^dSGA1^bSHC1^bSPS100^b^,^c^,^dUBC5^bUBI4^bUBX6^bYNL194C^cYOR388W^b^,^d
Downregulated genes
Cell cycle	15.09	9.81	9.85 × 10⁻³	ARP1^cCLB1^b^,^cCLB2^b^,^cCLB6^b^,^cDAD2^cFAR1^b^,^cFUS3^b^,^c^,^dHOF1^b^,^cKAR4^cMAK16^b^,^cMCD1^b^,^cNDJ1^b^,^cNIS1^b^,^cPCL9^b^,^cPOL30^b^,^cPTC2^b^,^cSPC24^b^,^cSPO16^cSUN4^b^,^cTUB1^b^,^cYGR271C-A^cYHP1^b^,^c
Ribosome biogenesis	15.09	11.98	4.45 × 10⁻²	ADE4^b^,^cALB1^b^,^cARP1^cCYB5^b^,^cDFR1^b^,^cEBS1^b^,^cFAF1^bFAR1^b^,^cFRE1^b^,^dFYV7^b^,^cGFD2^b^,^cMAK16^b^,^cMRT4^b^,^cMTD1^b^,^cPHO3^b^,^cRPS28B^b^,^cSER2^b^,^cSRD1^b^,^cYGR271C-A^cYOR305W^cYPL279C^b^,^cZRT2^b
Conjugation	11.95	2.0	5.58 × 10⁻¹⁰	AGA1^b^,^cAGA2^b^,^cFAR1^b^,^cFIG1^b^,^cFIG2^bFUS1^cFUS3^b^,^c^,^dKAR4^cMF(ALPHA)2^b^,^cMFA1^b^,^cPRM1^cPRM2^bPRM3^bPRM6^b^,^cSAG1^b^,^cSST2^b^,^cSTE2^b^,^cSTE3^cTUB1^b^,^c
Translation	11.32	17.38	1.03 × 10⁻²	AAC3^b^,^cADE17^cADH4^cADK2^cANB1^b^,^cEBS1^b^,^cFAR1^b^,^cFSH1^b^,^cHEM13^b^,^cPMU1^cPTC2^b^,^cRPS28B^b^,^cSHM2^b^,^cSST2^b^,^cYMR010W^cYOR302W^b
Amino acid metabolism	8.18	4.2	9.70 × 10⁻³	ACO1^b^,^cADE4^b^,^cADH4^cDFR1^b^,^cDIC1^cGCV1^cGCV2^cMHT1^bSER2^b^,^cSHM2^b^,^c
Signal transduction	7.55	4.8	3.86 × 10⁻²	FAR1^b^,^cFUS3^b^,^c^,^dMF(ALPHA)2^b^,^cMFA1^b^,^cMSB4^b^,^cPTC2^b^,^cRPI1^b^,^cSST2^b^,^cSTE2^b^,^cSTE3^cTEC1^b^,^cYIL169C^b
Meiosis	5.66	3.01	2.94 × 10⁻²	CLB1^b^,^cKAR4^cNDJ1^b^,^cPOL30^b^,^cSPO16^cTUB1^b^,^cYHP1^b^,^c

Data (for 296 upregulated genes and 161 downregulated genes) were organized into GO-based biological process categories using the GO Term Mapper tool (http://go.princeton.edu/cgi-bin/GOTermMapper). Significantly overrepresented categories (P value, ≤0.05) with a PFA data set frequency of ≥5% are listed.

Gene responsive to 200 mM CaCl₂ (15 and 30 min) (37).

Gene responsive to 15 μM amiodarone (10 min) (38).

Gene associated with calcineurin (37) and/or Crz1 (http://www.yeastract.com) (34).