FIG. 3.

Dose-dependent activity of pyrazinamide (Z) against chronic murine TB. Mice were aerosol infected with M. tuberculosis H37Rv, and antibiotic treatment was initiated 28 days later (day 0). Mice were randomized to one of the following regimens: no treatment (untreated), isoniazid at 10 mg/kg (H10), Z at 37.5 mg/kg (Z37.5), Z at 75 mg/kg (Z75), Z at 150 mg/kg (Z150), or Z at 300 mg/kg (Z300). Mice were treated with antibiotics five times weekly for a total of 28 days. ***, P = 0.00001; **, P = 0.002; *, P = 0.03. The data represent mean CFU counts per lung ± the standard deviation. n = 5 mice per data point.