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. 2011 Jan 31;55(4):1527–1532. doi: 10.1128/AAC.01524-10

FIG. 4.

FIG. 4.

Dose-dependent activity of pyrazinamide (Z) and synergistic activity of Z and rifampin (R) against chronic guinea pig TB. Guinea pigs were aerosol infected with M. tuberculosis H37Rv, and antibiotic treatment was initiated 28 days later (Day 0). Guinea pigs were randomized to one of the following regimens: no treatment (untreated), isoniazid at 60 mg/kg (H60); Z at 75 mg/kg (Z75), Z at 150 mg/kg (Z150), Z at 300 mg/kg (Z300), Z at 600 mg/kg (Z600), R at 50 mg/kg (R50), or R (50 mg/kg) plus Z (300 mg/kg) (R50Z300). Guinea pigs were treated with antibiotics five times weekly for a total of 28 days. ***, P = 0.0009; **, P = 0.001; *, P = 0.02; ****, P = 0.001 for multiplicative as opposed to additive interaction of R and Z by linear regression model. The data represent mean CFU counts per lung ± the standard deviation. n = 4 guinea pigs per data point.