TABLE 2.

Razupenem T>MIC targets required for a bacteriostatic effect and for 1-, 2-, and 3-log-unit reductions in S. aureus viable counts at 24 h and 48 h

Time (h)	Effect	T>MIC (%) for strain (MIC, mg/liter):
		MSSA 5956 (0.015)	MRSA 33922 (0.09)	MRSA 36895 (0.38)	VISA 19898 (1.5)	MRSA 27706 (1.5)	MRSA 33820 (3.0)	MRSA, avg ± SD	MRSA, pooled analysis
24	Static	23.6	6.7	4.5	3.9	6.4	3.6	5.0 ± 1.4	4.0
	1.0-log-unit reduction	31.5	13.4	18.4	7.3	17.7	5.7	12.5 ± 5.8	9.0
	2.0-log-unit reduction	40.9	23.5	31.9	11.8	33.3	9.2	21.9 ± 11.1	16.1
	3.0-log-unit reduction	53.0	40.9		18.9	59.1		36.6 ± 20.1	31.4
	r2	0.685	0.881	0.910	0.958	0.807	0.882		0.800
48	Static	31.5	12.8	9.7	10.3	6.4	6.0	9.0 ± 2.8	7.8
	1.0-log-unit reduction	35.9	23.5	16.8	13.7	11.8	7.6	14.7 ± 5.9	14.1
	2.0-log-unit reduction	39.6	36.2	25.2	17.2	19.5	9.2	21.5 ± 10.4	22.1
	3.0-log-unit reduction	45.0	55.0	38.0	22.3	35.5	12.2	32.6 ± 16.3	34.9
	r2	0.972	0.984	0.963	0.966	0.8639	0.895		0.881