TABLE 5.
Razupenem T>MIC targets required for a bacteriostatic effect and for 1-, 2-, and 3-log-unit reductions in Enterobacteriaceae viable counts at 24 h and 48 h
| Time (h) | Effect |
T>MIC (%) for strain (MIC, mg/liter): |
||||||
|---|---|---|---|---|---|---|---|---|
| E. coli 31053 (SHV-12+) (0.09) | E. coli 35776 (CTXM+) (0.1) | E. coli 39136 (Amps) (1.2) | Enterobacter sp. strain 35054 (0.4) | Enterobacter sp. strain 34425 (6) | Avg ± SD | Pooled analysis | ||
| 24 | Static | 31.7 | 47.0 | 35.0 | 27.5 | 30.2 | 34.3 ± 7.6 | 32.4 |
| 1.0-log-unit reduction | 40.9 | 55.5 | 40.9 | 34.2 | 40.9 | 42.5 ± 7.8 | 41.5 | |
| 2.0-log-unit reduction | 49.7 | 64.1 | 46.7 | 42.3 | 51.3 | 50.6 ± 8.2 | 50.5 | |
| 3.0-log-unit reduction | 61.7 | 74.0 | 52.6 | 52.3 | 65.8 | 61.3 ± 9.2 | 61.5 | |
| 4.0-log-unit reduction | 92.6 | 89.4 | 63.6 | 87.9 | 83.4 ± 13.3 | 83.9 | ||
| r2 | 0.981 | 0.975 | 0.963 | 0.957 | 0.943 | 0.929 | ||
| 48 | Static | 39.8 | 50.6 | 44.8 | 37.6 | 39.3 | 42.2 ± 5.3 | 38.5 |
| 1.0-log-unit reduction | 40.3 | 61.2 | 47.4 | 39.6 | 43.5 | 46.4 ± 8.8 | 45.2 | |
| 2.0-log-unit reduction | 40.9 | 71.0 | 50.6 | 41.6 | 47.7 | 50.4 ± 12.2 | 52.5 | |
| 3.0-log-unit reduction | 81.6 | 52.6 | 57.0 | 53.6 | 61.2 ± 13.7 | 63.9 | ||
| 4.0-log-unit reduction | 95.4 | 58.4 | 76.9 | |||||
| r2 | 0.829 | 0.949 | 0.960 | 0.944 | 0.803 | 0.853 | ||