TABLE 6.
Changes in Enterobacteriaceae razupenem population profiles at 24 h and 48 h
| Time (h) | T>MIC range (%) | Growth on: |
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|---|---|---|---|---|---|---|---|
| 2× MIC recovery plates |
4× MIC recovery plates |
8× MIC recovery plates |
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| No. (%) of expts with >2-log-unit growth/total | Viable count (log CFU/ml), mean ± SD | No. (%) of expts with >2-log-unit growth/total | Viable count (log CFU/ml), mean ± SD | No. (%) of expts with >2-log-unit growth/total | Viable count (log CFU/ml), mean ± SD | ||
| 24 | 1-9 | 4/4 (100) | 8.1 ± 0.1 | 4/4 (100) | 7.3 ± 1.1 | 4/4 (100) | 5.6 ± 2.4 |
| 10-19 | 7/8 (87) | 7.3 ± 1.8 | 6/8 (75) | 7.0 ± 1.4 | 6/8 (75) | 6.0 ± 2.2 | |
| 20-29 | 7/7 (100) | 5.4 ± 2.6 | 3/7 (43) | 7.9 ± 0.1 | 3/7 (43) | 7.9 ± 0.1 | |
| 30-39 | 3/4 (75) | 6.4 ± 1.6 | 2/4 (50) | 5.9 | 2/4 (50) | 5.8 | |
| 40-49 | 5/9 (55) | 4.2 ± 1.1 | 3/9 (33) | 3.8 ± 1.3 | 3/9 (33) | 3.5 ± 0.9 | |
| 50-69 | 6/11 (54) | 3.8 ± 1.0 | 4/11 (36) | 4.2 ± 0.8 | 4/11 (36) | 3.2 ± 1.0 | |
| ≥70 | 3/14 (21) | 2.7 | 0/14 | <2 | 0/14 | <2 | |
| 48 | 1-9 | 4/4 (100) | 8.2 ± 0.1 | 4/4 (100) | 7.5 ± 1.3 | 4/4 (100) | 6.5 ± 1.6 |
| 10-19 | 8/8 (100) | 7.6 ± 1.5 | 7/8 (87) | 7.7 ± 0.9 | 6/8 (75) | 7.1 ± 1.4 | |
| 20-29 | 7/7 (100) | 7.0 ± 2.2 | 6/7 (86) | 6.5 ± 2.6 | 5/7 (71) | 7.2 ± 2.1 | |
| 30-39 | 4/4 (100) | 7.2 ± 1.9 | 4/4 (100) | 5.7 ± 2.9 | 3/4 (75) | 6.8 ± 2.3 | |
| 40-49 | 8/9 (89) | 4.0 ± 1.3 | 4/9 (44) | 3.7 ± 1.0 | 3/9 (33) | 3.6 ± 0.9 | |
| 50-69 | 8/11 (73) | 3.9 ± 1.5 | 4/11 (36) | 5.2 ± 0.2 | 4/11 (36) | 4.8 ± 0.1 | |
| ≥70 | 5/14 (36) | 2.9 ± 0.4 | 2/14 (14) | 2.9 ± 0.1 | 2/14 (14) | 2.3 ± 0.2 | |