TABLE 6.
Group | Dose (no. of CFU/mouse) | Study day | Wt gain (g)b | Stomach wt (g)d | No. of animals with increase in following characteristic/total no. animals per group: |
No. of DNA copies of H. pylori/stomachd | Total no. of ulcers/stomach | H. pylori pathogenicity ratioc,d | ||
---|---|---|---|---|---|---|---|---|---|---|
Peyer's patches | Spleen wt | Mesenteric ganglion wt | ||||||||
A | Placebo | 14 | −0.90 ± 0.60 | 0.174 ± 0.035 D | 4/5 | 1/5 | 1/5 | 2.1 × 106 ± 1.9 × 106 F | 1.00 ± 0.71 | 0.85 ± 0.90 H |
21 | 0.06 ± 0.45 | 0.132 ± 0.032 D | 5/5 | 0/5 | 1/5 | 3.6 × 107 ± 6.0 × 107 F | 0.60 ± 0.89 | 0.02 ± 0.03 H | ||
B | 1 × 109 | 14 | −0.36 ± 0.76 | 0.166 ± 0.038 E | 2/5 | 0/5 | 0/5 | 4.4 × 106 ± 3.5 × 106 G | 0.60 ± 0.55 | 0.13 ± 0.14 I |
21 | −0.20 ± 0.37 | 0.132 ± 0.013 E | 2/5 | 0/5 | 0/5 | 4.9 × 107 ± 3.0 × 107 G | 0.00 ± 0.00 | 0.00 ± 0.00 I |
Data are the means ± standard deviations of the means (n = 5).
Body weight gain is expressed as final weight minus initial weight.
H. pylori pathogenicity ratio is expressed as total number of ulcers per million copies of H. pylori DNA in the stomach.
Pairs of values sharing the same capital letter are significantly different (P < 0.05).