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. 2010 Dec 30;77(5):1770–1776. doi: 10.1128/AEM.02151-10

TABLE 1.

Sensitivity of yeast mutants to 2,4-DAPG compared with results of published chemical screens (Tc > 0.2 and Hp < 1.00e−30)

Compound Overlapping scorea Overlapping significanceb Reference
Menthol 0.25 <1.00e−30 41
Sodium azide 0.23 <1.00e−30 41
Hydrogen peroxide 0.21 <1.00e−30 41
a

Tanimoto coefficient (Tc) is used as the overlapping score between the query profile (2,4-DAPG) and the target profiles (published fitness profiles). When two profiles are perfectly overlapped, Tc is 1.

b

Hypergeometric P value (Hp) means the overlapping significance between query and target profiles compared with random overlapping chance. Lower Hp tends to indicate more significant overlapping between fitness profiles of two compounds, which are then likely to have more similar mechanisms of action.