TABLE 1.
Domain and structural predictions of putative proteins encoded by genes in the fox heme copper oxidase gene cluster
| Gene | Modeled? | Closest protein domain | Additional comment(s) |
|---|---|---|---|
| foxA | Yes | Heme Cu oxidase, subunit I | Three copies in genome of M. yellowstonensis |
| foxB | Yes | Cytochrome oxidase, subunit II | Contains conserved Cu-binding ligands for CuA center similar to SoxH |
| foxC | Yes (also see Results) | Cytochrome b558/566, subunit A (pairs with FoxD) | Candidate for Fe(II) oxidation (also see Results) |
| foxD | No | Cytochrome b558/566, subunit B (pairs with FoxC) | 10 transmembrane helices |
| foxE | No | Cytochrome c oxidase assembly factor (CtaG) | 6 transmembrane helices |
| foxF | No | Faint structural similarity to a cbb3-type cytochrome oxidase, subunit I (also similar to FoxA) | 12 transmembrane helices |
| foxG | Yes | Structurally similar to the CcoG protein required for biogenesis of cbb3-type cytochrome c oxidase | 9 transmembrane helices; NapH ferredoxin fold |
| foxH | Partial | Two cystathionine-beta-synthase domains, bind adenosyl group ligands (e.g., AMP, ATP S-AdoMet) | Senses changes in AMP/ATP ratios |
| foxI | Yes | Cu resistance protein, CopC | Binds Cu |
| foxJ | No | Cytochrome oxidase subunit III | 7 transmembrane helices |