TABLE 4.
Identification of potential biomarker genes that might be used to distinguish Cronobacter and Salmonella spp. from other food-borne pathogens based on literature-based data mining
| C. sakazakiilocus tag | C. sakazakiiprotein accession no. (GenBank) | Gene/protein name (symbol) | Presence of homology |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Salmonella | Citrobacter | E. coli | Klebsiella | Clostridium | Pantoea | Yersinia | Shigella | E. cloacae | Campylobacter/Listeria | |||
| ESA_01183 | YP_001437286.1 | Wzx | Yes | No | Yes | No | No | No | No | No | No | No |
| ESA_01185 | YP_001437288.1 | Wzy | No | No | No | No | No | No | No | No | No | No |
| ESA_03317 | YP_001439374.1 | Chitinase | Yes | Yes | No | No | No | No | No | No | No | No |
| ESA_02201 | YP_001438286.1 | Hypothetical protein | No | No | No | No | No | No | No | No | No | No |
| ESA_02709 | YP_001438777.1 | α-1,4-Glucosidase gene (gluA) | No | No | No | No | Yes | No | No | No | No | No |
| ESA_02516 | YP_001438597.1 | Putative hemolysin/hemagglutinin | No | No | No | No | No | No | No | No | No | No |
| ESA_02084 | YP_001438170.1 | Putative adhesin | No | No | No | No | No | No | No | No | No | No |
| ESA_00341 | YP_001436476.1 | Beta-carotene hydroxylase pigment (crtZ) | No | No | No | No | No | Yes | No | No | No | No |
| ESA_00341 | YP_001436477.1 | Phytoene/squalene synthetase (crtB) | No | No | No | No | No | Yes | No | No | No | No |
| ESA_00343 | YP_001436478.1 | Phytoene dehydrogenase (crtI) | No | No | No | No | No | Yes | No | No | No | No |
| ESA_00344 | YP_001436479.1 | Lycopene cyclase (crtL) | No | No | No | No | No | Yes | No | No | No | No |
| ESA_00345 | YP_001436480.1 | Glycosyl transferases (crtX) | No | No | No | No | No | Yes | No | No | No | No |
| ESA_00346 | YP_001436481.1 | Isopentenyl pyrophosphate isomerase | No | No | No | No | No | Yes | No | No | No | No |
| ESA_00347 | YP_001436482.1 | Geranylgeranyl pyrophosphate synthase (crtE) | No | No | No | No | No | Yes | No | No | No | No |
| ESA_03721 | YP_001439754.1 | DNase (TatD) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_02154 | YP_001438239.1 | Succinylarginine dihydrolase | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_02391 | YP_001438473.1 | Outer membrane protein A (ompA) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_00314 | YP_001436449.1 | Ornithine decarboxylase | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_01872 | YP_001437962.1 | Catalase | Yes | Yes | Yes | Yes | No | No | No | Yes | No | No |
| ESA_01203 | YP_001437307.1 | 4-Aminobutyrate aminotransferase | No | Yes | Yes | Yes | No | No | No | Yes | No | No |
| ESA_01574 | YP_001437664.1 | Aconitate hydratase | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_04127 | YP_001440144.1 | 6-Phosphofructokinase | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_01954 | YP_001438044.1 | Fumarate/nitrate reduction transcriptional regulator | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_04154 | YP_001440171.1 | Alpha-xylosidase (YicI) | Yes | Yes | Yes | Yes | Yes | No | No | Yes | Yes | No |
| ESA_00357 | YP_001436490.1 | DNA primase (dnaG) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_03853 | YP_001439875.1 | Galactoside permease | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_04206 | YP_001440222.1 | Endo-1,4-d-glucanase (BscZ) | Yes | Yes | Yes | Yes | No | No | Yes | Yes | Yes | No |
| ESA_00523 | YP_001436650.1 | Phosphopyruvate hydratase | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_03753 | YP_001439786.1 | Porphobilinogen deaminase | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_00373 | YP_001436507.1 | Outer membrane channel protein | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_02807 | YP_001438873.1 | Acriflavin resistance protein A precursor (AcrA) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_03723 | YP_001439756.1 | sec-independent translocase (TatB) | Yes | Yes | Yes | Yes | No | No | Yes | Yes | Yes | No |
| ESA_02187 | YP_001438272.1 | Virulence protein (VirK) | Yes | Yes | Yes | Yes | No | No | Yes | Yes | No | No |
| ESA_02251 | YP_001438336.1 | Acyl carrier protein | Yes | No | Yes | No | No | Yes | Yes | No | No | No |
| ESA_00752 | YP_001436865.1 | Extracellular metalloprotease Prt1 | Yes | Yes | No | No | No | Yes | No | No | No | No |
| ESA_00690 | YP_001436805.1 | GTP-binding protein (lepA) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_04401 | YP_001440417.1 | Elongation factor G | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_03312 | YP_001439369.1 | Isoleucyl-tRNA synthetase (ileS) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_03973 | YP_001439995.1 | DNA gyrase subunit B (gyrB) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_03690 | YP_001439730.1 | DNA-directed RNA polymerase subunit beta (rpoB) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| GU122171 | GU122171 | 16S rRNA | No | No | No | No | No | No | No | No | No | No |
| ACE74909 | ACE74909 | ATPase (RecN) | Yes | Yes | Yes | Yes | No | No | No | Yes | Yes | No |
| ESA_00031 | YP_001436176 | DNA-directed RNA polymerase subunit alpha (rpoA) | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | No |
| ESA_03979 | YP_001440001.1 | tRNA modification GTPase TrmE (thdF) | Yes | Yes | Yes | Yes | No | No | No | Yes | Yes | No |