FIG. 5.

The 3-hydroxypropionate (Fuchs-Holo) bi-cycle (130). Enzymes: 1, acetyl-CoA carboxylase; 2, malonyl-CoA reductase; 3, propionyl-CoA synthase; 4, propionyl-CoA carboxylase; 5, methylmalonyl-CoA epimerase; 6, methylmalonyl-CoA mutase; 7, succinyl-CoA:(S)-malate-CoA transferase; 8, succinate dehydrogenase; 9, fumarate hydratase; 10a, -b, and -c, trifunctional (S)-malyl-CoA (a)/β-methylmalyl-CoA (b)/(S)-citramalyl-CoA lyase (c); 11, mesaconyl-C1-CoA hydratase; 12, mesaconyl-CoA C1-C4 CoA transferase; 13, mesaconyl-C4-CoA hydratase. (Reprinted from reference 130 with permission.)