TABLE 1.
Association of TLR polymorphisms with Streptococcus pyogenes (GAS) infections in patients with tonsillar diseasea
| Variable | GAS-positive patients | GAS-negative patients | P valueb | OR (95% CI) |
|---|---|---|---|---|
| No. of patients | 38 | 289 | ||
| Mean ± SD age (yr) | 9.2 ± 7.13 | 13.1 ± 11.1 | 0.430 | |
| No. (%) below age 14 yr | 32 (84.2) | 182 (64.6) | 0.011 | 0.32 (0.13-0.81) |
| No. (%) above age 14 yr | 6 (15.8) | 104 (36.4) | ||
| Sex (no. male/no. female) | 19/19 | 154/135 | 0.732 | 0.87 (0.44-1.72) |
| TLR4-D299G | ||||
| No. (%) of patients with genotype: | ||||
| A/A (wt) | 30 (78.9) | 264 (91.3) | 0.038 | 2.81 (1.16-6.79) |
| A/G (het) | 8 (21.1) | 25 (8.7) | ||
| G/G (hom) | 0 (0) | 0 (0) | ||
| No. (%) of patients with allele with: | ||||
| A | 68 (89.4) | 553 (95.6) | 0.044 | 2.6 (1.12-5.99) |
| G | 8 (10.5) | 25 (4.3) | ||
| TLR4-T399I | ||||
| No. (%) of patients with genotype: | ||||
| C/C (wt) | 29 (76.3) | 262 (90.7) | 0.023 | 3.01 (1.29-7.02) |
| C/T (het) | 9 (23.7) | 27 (9.3) | ||
| T/T (hom) | 0 (0) | 0 (0) | ||
| No. (%) of patients with allele with: | ||||
| C | 67 (88.1) | 551 (95.3) | 0.027 | 2.74 (1.23-6.07) |
| T | 9 (11.8) | 27 (4.6) | ||
| TLR2-R753Q | ||||
| No. (%) of patients with genotype: | ||||
| G/G (wt) | 38 (100) | 282 (97.6) | 0.418 | 0.88 (0.84-0.91) |
| G/A (het) | 0 (0) | 7 (2.4) | ||
| A/A (hom) | 0 (0) | 0 (0) | ||
| No. (%) of patients with allele with: | ||||
| G | 76 (100) | 571 (98.7) | 0.419 | 0.97 (0.95-0.99) |
| A | 0 (0) | 7 (1.21) |
a
Comparisons of genotypes were carried out between wild-type and the sum of mutated alleles (the χ2 two-sided test was performed for TLR4 SNPs and the χ2 one-sided test was performed for TLR2-R753Q). Abbreviations: wt, wild type; het, heterozygous; hom, homozygous.
b
Boldface values indicate statistically significant differences.