TABLE 2.
Association of TLR polymorphisms with Haemophilus influenzae infections and/or carriage in patients with tonsillar diseasea
| Variable | H. influenzae-positive patients | H. influenzae-negative patients | P valueb | OR (95% CI) |
|---|---|---|---|---|
| No. of patients | 105 | 222 | ||
| Mean ± SD age (yr) | 13.1 ± 11.1 | 12.4 ± 10.7 | 0.887 | |
| No. (%) below age 14 yr | 65 (61.9) | 118 (53.2) | 0.153 | 0.69 (0.43-1.12) |
| No. (%) above age 14 yr | 40 (38.1) | 104 (46.8) | ||
| Sex (no. male/no. female) | 55/50 | 118/104 | 0.906 | 0.97 (0.61-1.54) |
| TLR4-D299G | ||||
| No. (%) of patients with genotype: | ||||
| A/A (wt) | 99 (94.2) | 195 (87.8) | 0.079 | 0.43 (0.17-1.09) |
| A/G (het) | 6 (5.7) | 27 (12.1) | ||
| G/G (hom) | 0 (0) | 0 (0) | ||
| No. (%) of patients with allele with: | ||||
| A | 204 (97.1) | 417 (93.9) | 0.087 | 0.45 (0.18-1.11) |
| G | 6 (2.8) | 27 (6.08) | ||
| TLR4-T399I | ||||
| No. (%) of patients with genotype: | ||||
| C/C (wt) | 99 (94.2) | 192 (86.4) | 0.038 | 0.38 (0.15-0.96) |
| C/T (het) | 6 (5.7) | 30 (13.5) | ||
| T/T (hom) | 0 (0) | 0 (0) | ||
| No. (%) of patients with allele with: | ||||
| C | 204 (97.1) | 414 (93.2) | 0.044 | 0.40 (0.16-0.99) |
| T | 6 (2.8) | 30 (6.7) | ||
| TLR2-R753Q | ||||
| No. (%) of patients with genotype: | ||||
| G/G (wt) | 102 (97.1) | 218 (98.2) | 0.685 | 1.62 (0.35-7.29) |
| G/A (het) | 3 (2.9) | 4 (1.8) | ||
| A/A (hom) | 0 (0) | 0 (0) | ||
| No. (%) of patients with allele with: | ||||
| G | 207 (98.5) | 440 (99.1) | 0.686 | 1.59 (0.35-7.18) |
| A | 3 (1.5) | 4 (0.9) |
a
Comparisons of genotypes were carried out between wild-type and the sum of mutated alleles (χ2 two-sided test). Abbreviations: wt, wild type; het, heterozygous; hom, homozygous.
b
Boldface values indicate statistically significant differences.