TABLE 1.
Neutralizing antibody response induced in vaccinated monkeys, measured by PRNT
| Monkey | Neutralizing antibody titer on daya: |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 (prime) | 30 | 60 | 90 (boost) | 120 | 150 | 180 | 210 | 270 | |
| 1 | <10 | 68 | 42 | 213 | 850 | 1,000 | 1,000 | 1,000 | 174 |
| 2 | <10 | 35 | 278 | 136 | 1,000 | 1,000 | 677 | 650 | 637 |
| 3 | <10 | 16 | 112 | 144 | 800 | 683 | 916 | 308 | 358 |
| GMT | <10 | 33.6 | 109.4 | 160.9 | 879.4 | 880.7 | 852.7 | 584.9 | 341.1 |
a
Results are given as antibody titers and are representative of those from three independent experiments. The neutralizing antibody titer is the highest serum dilution that resulted in a 50% reduction in the number of plaques produced by DEN-2. The prime consisted of infection with DEN-2, and the boost consisted of inoculation of the recombinant domain III-capsid protein.