TABLE 1.
GMCs of IgG antibodies to individual pneumococcal capsular polysaccharides in pre- and postvaccination sera from middle-aged and elderly subjects according to vaccine status
| Group (n) | IgG GMC (95% CI) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Serotype 6B |
Serotype 14 |
Serotype 19F |
Serotype 23F |
|||||
| Prevaccination | Postvaccinationb | Prevaccination | Postvaccinationb | Prevaccination | Postvaccinationb | Prevaccination | Postvaccinationb | |
| Middle-aged subjects (36) | 1.97 (1.46-2.65) | 3.03 (2.35-3.92) | 3.26 (2.38-4.47) | 9.33 (6.33-13.74) | 2.09 (1.66-2.64) | 3.46 (2.55-4.70) | 1.21 (0.92-1.59) | 2.23 (1.65-3.00) |
| Vaccine-naïve subjects (18) | 1.68 (1.17-2.40) | 2.73 (2.01-3.71) | 2.06 (1.59-2.67) | 11.20 (5.51-22.06) | 1.85 (1.31-2.61) | 3.14 (1.82-5.41) | 0.94 (0.63-1.39) | 2.04 (1.36-3.05) |
| Previously vaccinated subjects (18) | 2.30 (1.39-3.80) | 3.36 (2.17-5.22) | 5.17a (3.10-8.63) | 7.89 (5.20-11.97) | 2.36 (1.68-3.31) | 3.81 (2.70-5.36) | 1.57 (1.09-2.26) | 2.43 (1.51-3.93) |
| Elderly subjects (40) | 2.21 (1.67-2.93) | 3.18 (2.26-4.49) | 3.89 (2.81-5.41) | 7.45 (5.19-10.68) | 2.59 (2.07-3.24) | 4.02 (3.03-5.33) | 1.24 (0.97-1.59) | 2.73 (1.94-3.85) |
| Vaccine-naïve subjects (22) | 1.99 (1.34-2.97) | 3.32 (1.91-5.77) | 2.67 (1.78-4.00) | 6.65 (3.97-11.14) | 2.25 (1.67-3.04) | 3.33 (2.17-5.09) | 1.07 (0.77-1.48) | 2.98 (1.75-5.08) |
| Previously vaccinated subjects (18) | 2.51 (1.63-3.85) | 3.02 (1.98-4.61) | 6.20a (3.80-10.11) | 8.55 (4.95-14.75) | 3.07 (2.15-4.40) | 5.06 (3.49-7.33) | 1.50 (1.02-2.19) | 2.46 (1.56-3.87) |
a
Significant difference (P < 0.03) in log-converted prevaccination concentrations (μg/ml) between previously vaccinated and vaccine-naïve subjects.
b
Significant increases (P < 0.05) in IgG concentrations (within-group comparisons) were seen for all groups.