TABLE 2.
Geometric mean VH3 antibody titers to pneumococcal polysaccharide vaccine in pre- and postvaccination sera from middle-aged and elderly subjects according to vaccine statusa
| Group (n) | Geometric mean VH3 antibody titer (95% CI) |
|
|---|---|---|
| Prevaccination | Postvaccinationb | |
| Middle-aged subjects (31) | 6.48 (5.10-8.24) | 16.12 (10.92-23.78) |
| Vaccine-naïve subjects (16) | 5. 65 (4.73-6.74) | 21.60 (13.45-34.70) |
| Previously vaccinated subjects (15) | 7.51 (4.66-12.13) | 11.80 (6.18-22.49) |
| Elderly subjects (35) | 7.38 (5.87-9.27) | 20.86 (13.27-32.78) |
| Vaccine-naïve subjects (20) | 6.06 (4.81-7.63) | 21.05 (11.26-39.35) |
| Previously vaccinated subjects (15) | 9.59 (6.19-14.84) | 20.60 (9.84-43.16) |
a
No significant differences in log-converted pre- or postvaccination titers were seen between middle-aged and elderly subjects.
b
Significant increases (P < 0.03) in log-converted VH3 antibody titers (within-group comparisons) were seen for all groups.