Table 2.
Phenotypic features of fungal Skn7 orthologs
| Organism | Gene | Mutation(s) | Phenotypic feature(s)a |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Oxidant sensitivity | Osmotic sensitivity | Fungicide resistance | Thermal sensitivity | Wall stress sensitivity | Other | Virulence | |||
| C. glabrata | CgSKN7 | Deletion | + | NR | NR | NR | − | +/− | |
| C. albicans | CaSKN7 | Deletion | + | + | − | NR | − | Morphogenesis defects | +/− |
| C. neoformans | CnSKN7 | Deletion and insertion | Growth assays and OXR gene expression | − | + | ? | + | Sodium sensitivity, increased melanin, increased mating | + |
| P. marneffei | PmSKN7 | Complementation of the S. cerevisiae gene deletion | + | NR | NR | NR | NR | NR | |
| C. lusitaniae | ClSKN7 | Deletion | + | − | + | − | NR | Pseudohyphal defects | NR |
| A. fumigatus | AfSKN7 | Deletion | + | − | NR | − | + (SDS) | − | |
| C. heterostrophus | dic2/ChSKN7 | Partial and complete deletions and D359N | NR | +/− | + | NR | NR | NR | |
| (Flu and Ipr) | |||||||||
| M. oryzae | MoSKN7 | Deletion | − | +/− | + | NR | − | ||
| A. nidulans | srrA/AnSKN7 | Deletion | + including Men | +/− | + | NR | + (CFW) | Reduced asexual spore formation and conidiospore viability | NA |
| S. pombe | prr1/SpSKN7 | Deletion and D418N | + | − | NR | NR | − | Cold sensitivity, heavy metal sensitivity, and mating sporulation defects | NA |
| N. crassa | rrg2/NcSKN7 | Deletion | Slight | − | NR | − | NR | Conidiation and fertility defects | NA |
| S. cerevisiae | ScSKN7 | Deletion and D427N, D427E, T437A, and HSF domain mutations | HP, TB | − | NR | + | + | NA | |
a
+, full phenotype observed; +/−, modest phenotype observed; −, no phenotype observed. NR, not reported; NA, not applicable; HP, hydrogen peroxide; TB, tert-butyl hydroperoxide; Men, menadione; Flu, fludioxonil; Ipr, iprodione.