FIG. 1.

Pictorial representation of the genes in the LPS/capsule polysaccharide regions of Vibrio cholerae serogroups O1, O37, O22, O139, O31, O5, O8, O108, O12, O14, O39, O135, and O141, as well as those of strains 623-39, TMA 21, and VL426. We selected three strains, CO545, CO845, and CO603B, from serogroups O5, O8, and O108, respectively, for analysis based on carbohydrate analysis, which suggested that these serogroups have at least two sugars, glycero-d-manno-heptose and glucose, in common in their LPS (28). The sequences of the other serogroups were taken from the literature for comparison, with the expectation that there would be identifiable subgroups. Flanking genes gmhD and rjg, which delineate the region, are marked in black. ORFs between these loci are numbered. JUMPstart sites are indicated by a diamond. Similar genes present in more than two rfb regions are color coded. Transport genes are marked in green; galE and wbeW genes are red; rhamnose pathway genes are marked in blue; wecB, wecE, and wecC are pink; and wbfY is brown. The unlabeled genes represented by white boxes are not found in common across the regions.