Fig. 6.
System biology for the propolis sensitivity in S. cerevisiae. (A) A physical protein-protein interaction (PPPI) network obtained from yeast deletion data whose absence increases the sensitivity of yeast cells to propolis treatment. (B) Distribution of proteins (number of nodes) associated with propolis-induced sensitivity as observed from yeast deletion data in the different clusters and unclustered proteins of the major PPPI network. Cluster 1, translation/energy derivation by oxidation of organic compounds/mitochondrial genome maintenance; cluster 2, transcription/chromosome organization and biogenesis/G1 phase of mitotic cell cycle; cluster 3, carboxylic acid metabolic process/protein targeting to peroxisome/respiration metabolism; cluster 4, establishment and/or maintenance of chromatin architecture/histone deacetylation; cluster 5, RNA catabolic process; cluster 6, cell division mechanisms; and unclustered nodes.