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. 2010 Dec 13;79(3):1349–1362. doi: 10.1128/IAI.00984-10

FIG. 9.

FIG. 9.

ifnγ−/− mice exhibit enhanced genital tract pathology and an amplified neutrophil response to C. muridarum genital infection. Genital tract tissues were removed en bloc from C. muridarum-infected mice 35 days postinfection (C57BL/6, n = 21; ifnγ−/−, n = 15). Tissues were scored for neutrophilic (polymorphonuclear leukocytes [PMNs]) and lymphocytic and monocytic inflammation. Histopathologic analysis of the oviducts (A to C), uterine horns (D to F), and mesosalpingeal tissues (G to I) of C57BL/6 (B, E, and H) and ifnγ−/− (C, F, and I) mice shows significantly increased neutrophil and lymphocyte/monocyte infiltration in tissues from ifnγ−/− mice (**, P < 0.002 by Mann-Whitney U test). The boxes extend from the 25th to 75th percentiles and the bars from the 5th to 95th percentiles. Photomicrographs of oviducts (C; magnification, ×4), uterine horns (F; magnification, ×20), and mesosalpingeal tissues (I; magnification, ×20) from ifnγ−/− mice demonstrate a marked increase in neutrophilic infiltrates, edema, and loss of tissue structure compared to similar tissues from C57BL/6 mice (oviducts [B; magnification, ×4], uterine horns [E; magnification, ×20], and mesosalpinx [H; magnification, ×20]).