TABLE 6.
T6SS-1 is required for virulence in the Syrian hamster model of infection
| Strain | T6SS targeted | No. of animals that succumbed/total no. infected witha: |
|||
|---|---|---|---|---|---|
| 10° | 101 | 102 | 103 | ||
| K96243 | None | 5/5 | 5/5 | 5/5 | ND |
| Δhcp1 mutant | T6SS-1 | 0/5 | 0/5 | 0/5 | 0/5 |
| Δhcp1/hcp1+ mutant | T6SS-1 | 4/5 | 5/5 | 5/5 | ND |
| Δhcp2 mutant | T6SS-2 | 4/5 | 5/5 | 5/5 | ND |
| Δhcp3 mutant | T6SS-3 | 5/5 | 5/5 | 5/5 | ND |
| Δhcp4 mutant | T6SS-4 | 5/5 | 5/5 | 5/5 | ND |
| Δhcp5 mutant | T6SS-5 | 5/5 | 5/5 | 5/5 | ND |
| Δhcp6 mutant | T6SS-6 | 4/5 | 4/5 | 5/5 | ND |
| ΔvgrG1-5′ mutant | T6SS-1 | 1/5 | 1/5 | 4/5 | ND |
| ΔvgrG1-5′/vgrG1+ mutant | T6SS-1 | 2/5 | 5/5 | 5/5 | ND |
| ΔvgrG1-3′ mutant | T6SS-1 | 0/5 | 0/5 | 0/5 | ND |
| ΔvgrG1-3′/vgrG1+ mutant | T6SS-1 | 3/5 | 5/5 | 5/5 | ND |
a
Groups of five female Syrian hamsters were infected i.p. with a range of 10° to 103 CFU for each strain examined. Mortality was recorded daily for 14 days. ND, not determined.