FIG. 7.

Chemokine production from wild-type and CCR5^−/− mice after S. mansoni infection. Mice were infected with 25 cercariae and evaluated 11 weeks after infection. CCL3 (A) and CCL5 (B) concentrations in the supernatants of spleen cells cultured in the absence (culture medium) or presence (SEA treated) of Schistosoma egg antigen were determined by ELISA. The values represent the averages ± SEM for 4 mice in each group. ***, P < 0.001 for infected versus noninfected mice of the same phenotype. ##, P < 0.01; ###, P < 0.001 (for wild-type versus CCR5^−/− mice at the same time point in infection).