FIG. 2.

Protein sequence alignment of C. sakazakii Cpa with known omptins: Pla of Y. pestis, OmpT of E. coli, and PgtE of S. enterica. Sequences were aligned by using the MEGA4 program (60). Residues important for proteolytic activity are in boldface, putative important residues for Pla subfamily substrate specificity are in marked by an asterisk (13), and the predicted surface-exposed loops determined for OmpT are indicated by L1 to L5 (62). Amino acid residues are numbered according to Pla sequence.