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. 2010 Dec 30;193(5):1154–1160. doi: 10.1128/JB.00459-10

FIG. 3.

FIG. 3.

Architecture of the proteins encoded by rv0465c and rv1129c. The deduced amino acid sequences of Rv0465c and Rv1129c were interrogated against an integrated database of protein domains and functional sites with the InterProScan package (http://www.ebi.ac.uk/Tools/InterProScan/). The analysis revealed that the two proteins belong to a protein family sharing a three-domain architecture: HTH_3 is a helix-turn-helix, DNA-binding motif; DUF955 (IPR010359) is a domain of unknown function; and DUF2083 (IPR018653) is annotated as a predicted transcriptional regulator found in the XRE family of prokaryotic transcriptional regulatory proteins (http://dbtbs.hgc.jp/ver1/tfactable.html). Rv0465c and Rv1129c are members of a ubiquitous protein family and are widely distributed in Mycobacteriaceae (see Fig. S3 in the supplemental material).