Table 2.
Sensitivity and specificity of the AHPV assay, the HC2 test, and cytology for CIN2+ and CIN3+ specimens from all women independent of age and in women <30 and ≥30 years of agea
| Status | Assay | Sensitivity |
Specificity |
||
|---|---|---|---|---|---|
| % | 95% CI | % | 95% CI | ||
| All women | |||||
| CIN2+ (n = 252) | AHPV | 91.70 | (87.6–94.5) | 75.00 | (68.0–80.9) |
| HC2 | 91.30 | (87.1–94.2) | 61.00 | (53.6–68.0) | |
| Cytology | 84.90 | (80.0–88.9) | 66.30 | (58.9–72.9) | |
| CIN3+ (n = 163) | AHPV | 98.20 | (94.7–99.4) | 56.30 | (50.3–62.2) |
| HC2 | 95.70 | (91.4–97.9) | 46.00 | (40.0–52.0) | |
| Cytology | 93.90 | (89.1–96.6) | 54.40 | (48.3–60.3) | |
| Women <30 yr | |||||
| CIN2+ (n = 81) | AHPV | 92.60 | (84.8–96.6) | 72.70 | (59.8–82.8) |
| HC2 | 92.60 | (84.8–96.6) | 50.90 | (38.1–65.6) | |
| Cytology | 85.20 | (75.9–91.3) | 58.20 | (45.0–70.3) | |
| CIN3+ (n = 41) | AHPV | 97.60 | (87.7–99.6) | 47.40 | (37.6–57.3) |
| HC2 | 97.60 | (87.7–99.7) | 34.70 | (25.9–44.7) | |
| Cytology | 97.60 | (87.7–99.6) | 45.30 | (35.6–55.3) | |
| Women ≥30 yr | |||||
| CIN2+ (n = 171) | AHPV | 91.20 | (86.0–94.6) | 76.10 | (67.6–82.9) |
| HC2 | 90.10 | (84.7–93.7) | 65.00 | (56.0–73.0) | |
| Cytology | 84.80 | (78.7–89.4) | 70.90 | (62.2–78.4) | |
| CIN3+ (n = 122) | AHPV | 98.40 | (94.2–99.6) | 61.40 | (53.9–68.5) |
| HC2 | 95.10 | (89.7–97.8) | 52.40 | (44.8–59.9) | |
| Cytology | 92.60 | (86.6–96.1) | 60.20 | (52.7–67.4) | |
a
95% confidence interval values calculated by the Score method are given.