Table 3.
Genotyping of disease-positive specimens missed by the AHPV assay or the HC2 testa
| Disease-positive specimens missed by: | Histology | No. of samples | No. of samples not genotyped | Linear Array HPV genotyping (no. of samples) |
||
|---|---|---|---|---|---|---|
| Negative | Low-risk HPV | High-risk HPV | ||||
| AHPV | CIN2 | 18 (7 HC2+) | 2 (1 HC2+) | 8 (1 HC2+) | 5 (4 HC2+) | 3 (1 HC2−) |
| CIN3 | 2 (1 HC2+) | 1 (HC2−) | 0 | 0 | 1 (HC2+) | |
| Cervical carcinoma | 1 (HC2+) | 0 | 0 | 1* (HC2+) | 0 | |
| HC2 | CIN2 | 15 (4 AHPV+) | 1 (AHPV−) | 7 (7 AHPV−) | 1 (AHPV−) | 6 (4 AHPV+) |
| CIN3 | 5 (4 AHPV+) | 0 | 1 (AHPV−) | 0 | 4 (4 AHPV+) | |
| Cervical carcinoma | 2 (2 AHPV+) | 0 | 1 (AHPV+) | 0 | 1 (AHPV+) | |
a
When several HPV genotypes were detected in a specimen, the specimen was categorized according to the “worst” genotype present (high risk being worse than low risk, and low risk being worse than negative). Result of the other assay shown in parentheses. *, this specimen contained low-risk HPV-53 as the only HPV type.