Table 2.
Partial outcomes for drug susceptibility testing of strains with different MICs
| Strain | MIC (mg/liter) | Medium durationb (mo) | Culture outcome of inoculated CFU counts (104/102)a at wk: |
|||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | |||
| H37Rv | 0.1–0.2 | Control | −/− | −/− | 2+/− | 3+/17 | 4+/20 | 4+/20 |
| 0 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 1 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 2 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 3 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 4 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 5 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 6 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 6039 | <0.05 | Control | −/− | −/− | C/Cc | 4+/31 | 4+/40 | 4+/40 |
| 0 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 1 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 2 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 3 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 4 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 5 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 6 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 6917 | 0.8–1.0 | Control | −/− | −/− | 3+/+ | 4+/+ | 4+/20 | 4+/40 |
| 0 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 1 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 2 | −/− | −/− | −/− | 2+/C | 3+/C | 4+/40 | ||
| 3 | −/− | −/− | −/− | 3+/+ | 4+/20 | 4+/40 | ||
| 4 | −/− | −/− | −/− | 3+/20 | 4+/50 | 4+/40 | ||
| 5 | −/− | −/− | −/− | 3+/− | 4+/10 | 4+/50 | ||
| 6 | −/− | −/− | +/− | 4+/20 | 4+/30 | 4+/60 | ||
| 6982 | 1.0–1.5 | Control | −/− | −/− | 2+/− | 3+/− | 4+/20 | 4+/50 |
| 0 | −/− | −/− | −/− | −/− | −/− | −/− | ||
| 1 | −/− | −/− | −/− | −/− | −/− | 12/− | ||
| 2 | −/− | −/− | −/− | −/− | −/− | 2+/3 | ||
| 3 | −/− | −/− | −/− | −/− | −/− | 2+/15 | ||
| 4 | −/− | −/− | −/− | −/− | −/− | 3+/15 | ||
| 5 | −/− | −/− | −/− | 2+/− | 4+/C | 4+/20 | ||
| 6 | −/− | −/− | C/− | 3+/− | 4+/C | 4+/11 | ||
| 6919 | 1.5–2.0 | Control | −/− | −/− | C/− | 3+/− | 3+/10 | 4+/20 |
| 0 | −/− | −/− | −/− | C/C | C/C | 3+/10 | ||
| 1 | −/− | −/− | −/− | C/C | C/C | 3+/15 | ||
| 2 | −/− | −/− | −/− | C/C | C/C | 4+/40 | ||
| 3 | −/− | −/− | −/− | C/C | C/C | 4+/20 | ||
| 4 | −/− | −/− | −/− | C/C | C/C | 4+/10 | ||
| 5 | −/− | −/− | C/− | 2+/C | 3+/C | 4+/8 | ||
| 6 | −/− | −/− | C/− | 3+/C | 3+/C | 4+/10 | ||
a
L-J medium culture grading criteria according to WHO guidelines.
b
Control indicates L-J medium without RIF.
c
“C” is the abbreviation for “conversion,” which indicates that very small colonies were observed but not enumerable.