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. 2011 Mar;49(3):1058–1063. doi: 10.1128/JCM.01904-10

Table 3.

Indicators of diagnostic test performance

Testa Resultb
Sensitivity (%) Specificity (%) PPV (%) NPV (%) LR+ LR−
≥1 positive result
    PCRm 57.7 (37.2–76) 94.4 (70.6–99.7) 93.8 (67.7–99.7) 60.7 (40.7–77.9) 10.4 (1.33–81.1) 0.45 (0.37–0.54)
    PCRr 50 (30.4–69.6) 66.7 (41.2–85.6) 68.4 (43.5–86.4) 48 (28.3–68.2) 1.50 (0.93–2.42) 0.75 (0.59–0.95)
    PCRm-PCRr 65.4 (44.4–82.1) 66.7 (41.2–85.6) 73.9 (51.3–88.9) 57.1 (34.4–77.4) 1.96 (1.33–2.89) 0.52 (0.38–0.70)
≥2 positive results
    PCRm 53.8 (33.7–72.9) 100 (78.1–100) 100 (73.2–100) 60 (40.7–76.8) 0.46 (0.39–0.54)
    PCRr 46.2 (27.1–66.3) 100 (78.1–100) 100 (69.9–100) 56.3 (37.9–73.2) 0.54 (0.47–0.62)
    PCRm-PCRr 65.4 (44.4–82.1) 94.4 (70.6–99.7) 94.4 (70.6–99.7) 65.4 (44.4–82.1) 11.8 (1.56–88.8) 0.37 (0.29–0.46)
a

PCRm, mitochondrial PCR; PCRr, ribosomal PCR; PCRm-PCRr, combination of both PCR assays.

b

PPV, positive predictive value; NPV, negative predictive value; LR+, likelihood ratio of a positive test; LR−, likelihood ratio of a negative test. The 95% CI is in parentheses.